ZK824859

• CAT Number: I016404
• CAS Number: 2254001-81-3
• Molecular Formula: C22H20F2N2O4
• Molecular Weight: 414.4
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CCC(C(=O)O)OC1=C(C=C(C(=N1)OC2=CC(=CC(=C2)C3=CC=CC(=C3)CN)C)F)F

ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.

Reference

[1] Imadul Islam, et al. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375.