For research use only. Not for therapeutic Use.
ZL0580（Cat No.:I017134） is a compound that is structurally similar to ZL0590 and has been found to induce epigenetic suppression of HIV. It works by selectively binding to the BD1 domain of the BRD4 protein, which is involved in the regulation of gene expression. By doing so, ZL0580 inhibits Tat transactivation and transcription elongation, leading to the suppression of HIV. Additionally, it induces a repressive chromatin structure at the HIV promoter, further contributing to the inhibition of viral replication.
| Catalog Number | I017134 |
| CAS Number | 2377151-10-3 |
| Molecular Formula | C₂₅H₂₃F₃N₄O₄S |
| Purity | ≥95% |
| IUPAC Name | (2S)-N-phenyl-1-[4-[[4-(trifluoromethyl)phenyl]carbamoylamino]phenyl]sulfonylpyrrolidine-2-carboxamide |
| InChI | InChI=1S/C25H23F3N4O4S/c26-25(27,28)17-8-10-19(11-9-17)30-24(34)31-20-12-14-21(15-13-20)37(35,36)32-16-4-7-22(32)23(33)29-18-5-2-1-3-6-18/h1-3,5-6,8-15,22H,4,7,16H2,(H,29,33)(H2,30,31,34)/t22-/m0/s1 |
| InChIKey | DKFYGSWCJGXEJY-QFIPXVFZSA-N |
| SMILES | C1CC(N(C1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C(F)(F)F)C(=O)NC4=CC=CC=C4 |
| Reference | [1]. Niu Q, et al. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J Clin Invest. 2019 Jul 22;129(8):3361-3373.<br>[2]. Vansant G, et al. Block-And-Lock Strategies to Cure HIV Infection. Viruses. 2020 Jan 10;12(1). pii: E84.<br>[3]. Brasier AR, et al. Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling. Drug Discov Today. 2020 Jan;25(1):126-132. |
