For research use only. Not for therapeutic Use.
Allosteric activator of AMP-activated protein kinase (AMPK; EC50 values 0.42 µM and 0.95 µM for increasing the activity of activated heterotrimers α1β1γ1 and α2β1γ1, respectively) that has no effect on mitochondrial function or the ADP/ATP ratio, and which exerts beneficial metabolic effects in vitro and in vivo. ZLN 024 reduced glucose intolerance and fatty liver characteristics in diabetic db/db mice and provides a promising therapeutic approach for type 2 diabetes mellitus and metabolic syndrome.
| Catalog Number | I004691 |
| CAS Number | 723249-01-2 |
| Molecular Formula | C13H13BrN2OS |
| Purity | ≥95% |
| IUPAC Name | 2-[2-(2-bromo-4-methylphenoxy)ethylsulfanyl]pyrimidine |
| InChI | InChI=1S/C13H13BrN2OS/c1-10-3-4-12(11(14)9-10)17-7-8-18-13-15-5-2-6-16-13/h2-6,9H,7-8H2,1H3 |
| SMILES | CC1=CC(=C(C=C1)OCCSC2=NC=CC=N2)Br |
| Reference | L.N. Zhang et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One. 2013 Aug 20;8(8):e72092. |
