For research use only. Not for therapeutic Use.
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. ZLN005 is a small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM. Chronic administration of 15 mg/kg/day ZLN005 to diabetic <em>db/db</em> mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity. This compound is the hydrochloride salt formulation of ZLN005 (Item No. <span class=/itemid/>14121</span>).
| Catalog Number | R067661 |
| Synonyms | 2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole, monohydrochloride |
| Molecular Formula | C17H18N2 • HCl |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C17H18N2.ClH/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16;/h4-11H,1-3H3,(H,18,19);1H |
| InChIKey | PRHDHWLJRJJOED-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C(C=C1)=CC=C1C2=NC3=CC=CC=C3N2.Cl |
| Reference | 1.Lin, J.,Handschin, C., and Spiegleman, B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metabolism 1, 361-370 (2005). |
