ZM 306416

• CAT Number: I004594
• CAS Number: 690206-97-4
• Molecular Formula: C16H13ClFN3O2
• Molecular Weight: 333.74
• Purity: ≥95%
• Synonyms: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
• Target: Src
• Solubility: DMSO: 67 mg/mL, H2O: ＜ 1 mg/mL
• Storage: 3 years -20C powder
• IC50: 0.67uM(VEGFR); 0.33±0.08uM(Src); 1.3±0.2 μM(Abl)
• InChI: InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)
• InChIKey: YHUIUSRCUKUUQA-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Cl)F)OC

ZM 306416（Cat No.:I004594）is a selective inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), which plays a critical role in angiogenesis, the process of new blood vessel formation that supports tumor growth and metastasis. By blocking VEGFR2 activity, ZM 306416 disrupts signaling pathways essential for vascular development, reducing tumor blood supply and inhibiting cancer progression. It has shown promise in preclinical models of cancer, particularly in targeting solid tumors that rely on angiogenesis. ZM 306416 is a valuable tool for studying VEGFR2-related processes and potential anti-angiogenic cancer therapies.

Reference

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