For research use only. Not for therapeutic Use.
ZM-241385（Cat No.:I001500） is a potent adenosine A2A receptor antagonist with high affinity. It specifically targets and blocks the adenosine A2A receptor, a G-protein-coupled receptor found in the central nervous system and other tissues. By inhibiting the A2A receptor, ZM-241385 interferes with adenosine-mediated signaling pathways. This antagonist has been extensively studied for its potential therapeutic applications, particularly in neurological and psychiatric disorders where the A2A receptor is involved, such as Parkinson’s disease and schizophrenia. Its high affinity for the receptor makes ZM-241385 a valuable tool for investigating adenosine A2A receptor function and developing novel treatments.
| Catalog Number | I001500 |
| CAS Number | 139180-30-6 |
| Synonyms | 4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)ethyl)phenol |
| Molecular Formula | C16H15N7O2 |
| Purity | ≥95% |
| Target | Adenosine Receptor |
| Solubility | DMSO: ≥ 30 mg/mL |
| Storage | Store at RT |
| InChI | InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22) |
| InChIKey | PWTBZOIUWZOPFT-UHFFFAOYSA-N |
| SMILES | OC1=CC=C(CCNC2=NC3=NC(C4=CC=CO4)=NN3C(N)=N2)C=C1 |
| Reference | </br>1:Binding kinetics of ZM241385 derivatives at the human adenosine A2A receptor. Guo D, Xia L, van Veldhoven JP, Hazeu M, Mocking T, Brussee J, Ijzerman AP, Heitman LH.ChemMedChem. 2014 Apr;9(4):752-61. doi: 10.1002/cmdc.201300474. Epub 2014 Mar 3. PMID: 24591302 </br>2:Effect of adenosine A2A receptor antagonist ZM241385 on amygdala-kindled seizures and progression of amygdala kindling. Li X, Kang H, Liu X, Liu Z, Shu K, Chen X, Zhu S.J Huazhong Univ Sci Technolog Med Sci. 2012 Apr;32(2):257-64. doi: 10.1007/s11596-012-0046-2. Epub 2012 Apr 20. PMID: 22528231 </br>3:Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine. Doré AS, Robertson N, Errey JC, Ng I, Hollenstein K, Tehan B, Hurrell E, Bennett K, Congreve M, Magnani F, Tate CG, Weir M, Marshall FH.Structure. 2011 Sep 7;19(9):1283-93. doi: 10.1016/j.str.2011.06.014. PMID: 21885291 Free PMC Article</br>4:Static magnetic field exposure reproduces cellular effects of the Parkinson/’s disease drug candidate ZM241385. Wang Z, Che PL, Du J, Ha B, Yarema KJ.PLoS One. 2010 Nov 8;5(11):e13883. doi: 10.1371/journal.pone.0013883. PMID: 21079735 Free PMC Article</br>5:The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices. Pugliese AM, Traini C, Cipriani S, Gianfriddo M, Mello T, Giovannini MG, Galli A, Pedata F.Br J Pharmacol. 2009 Jul;157(5):818-30. doi: 10.1111/j.1476-5381.2009.00218.x. Epub 2009 May 5. PMID: 19422385 Free PMC Article</br>6:ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. Li Q, Ye K, Blad CC, den Dulk H, Brouwer J, Ijzerman AP, Beukers MW.J Pharmacol Exp Ther. 2007 Feb;320(2):637-45. Epub 2006 Oct 31. PMID: 17077318 Free Article</br>7:Kinetic and functional properties of [3H]ZM241385, a high affinity antagonist for adenosine A2A receptors. Uustare A, Vonk A, Terasmaa A, Fuxe K, Rinken A.Life Sci. 2005 Feb 11;76(13):1513-26. Epub 2004 Dec 19. Erratum in: Life Sci. 2005 Jun 3;77(3):359. PMID: 15680315 </br>8:[(3)H]ZM241385–an antagonist radioligand for adenosine A(2A) receptors in rat brain. Alexander SP, Millns PJ.Eur J Pharmacol. 2001 Jan 12;411(3):205-10. PMID: 11164377 </br>9:Antagonism of coronary artery relaxation by adenosine A2A-receptor antagonist ZM241385. Arif Hasan AZ, Abebe W, Mustafa SJ.J Cardiovasc Pharmacol. 2000 Feb;35(2):322-5. PMID: 10672868 </br>10:ZM241385 is an antagonist of the facilitatory responses produced by the A2A adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus. Cunha RA, Constantino MD, Ribeiro JA.Br J Pharmacol. 1997 Dec;122(7):1279-84. PMID: 9421273 Free PMC Article |
