ZM39923 hydrochloride

• CAT Number: I000152
• CAS Number: 1021868-92-7
• Molecular Formula: C23H26ClNO
• Molecular Weight: 367.92
• Purity: ≥95%
• Synonyms: 3-(benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-one hydrochloride
• Target: Stem Cell/Wnt
• Solubility: DMSO: ≥ 47 mg/mL
• Storage: 3 years -20C powder
• IC50: 4.4/7.1 (pIC50)
• IUPAC Name: 3-[benzyl(propan-2-yl)amino]-1-naphthalen-2-ylpropan-1-one;hydrochloride
• InChI: InChI=1S/C23H25NO.ClH/c1-18(2)24(17-19-8-4-3-5-9-19)15-14-23(25)22-13-12-20-10-6-7-11-21(20)16-22;/h3-13,16,18H,14-15,17H2,1-2H3;1H
• InChIKey: NJTUORMLOPXPBY-UHFFFAOYSA-N
• SMILES: CC(C)N(CCC(=O)C1=CC2=CC=CC=C2C=C1)CC3=CC=CC=C3.Cl

ZM39923 hydrochloride(Cat No.:I000152) is a potent inhibitor targeting Janus kinase 1 (JAK1) and Janus kinase 3 (JAK3) enzymes. With a pIC50 of 4.4 for JAK1 and 7.1 for JAK3, ZM39923 effectively disrupts the activity of these kinases, which are involved in various signaling pathways. Notably, this compound exhibits minimal impact on Janus kinase 2 (JAK2) and shows modest potency against the epidermal growth factor receptor (EGFR). Additionally, ZM39923 hydrochloride demonstrates sensitivity to transglutaminase.