Zofenopril calcium

• CAT Number: I004970
• CAS Number: 81938-43-4
• Molecular Formula: C44H44CaN2O8S4
• Molecular Weight: 897.17
• Purity: ≥95%
• Synonyms: calcium (2S,4S)-1-((S)-3-(benzoylthio)-2-methylpropanoyl)-4-(phenylthio)pyrrolidine-2-carboxylate
• Target: ACE
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IUPAC Name: calcium;(2S,4S)-1-[(2S)-3-benzoylsulfanyl-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylate
• InChI: InChI=1S/2C22H23NO4S2.Ca/c2*1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17;/h2*2-11,15,18-19H,12-14H2,1H3,(H,25,26);/q;;+2/p-2/t2*15-,18+,19+;/m11./s1
• InChIKey: NSYUKKYYVFVMST-LETVYOFWSA-L
• SMILES: CC(CSC(=O)C1=CC=CC=C1)C(=O)N2CC(CC2C(=O)[O-])SC3=CC=CC=C3.CC(CSC(=O)C1=CC=CC=C1)C(=O)N2CC(CC2C(=O)[O-])SC3=CC=CC=C3.[Ca+2]

Zofenopril calcium (Cat No.: I004970) is a long-acting ACE inhibitor containing a sulfhydryl group in its chemical structural formula. It is a prodrug with lipophilicity and is hydrolyzed into a free sulfhydryl Zofen by esterase in vivo. Puli exerts its medicinal effect. Due to the effect of mercapto groups, it has stronger antioxidant properties. In addition to the effect of general ACEI in treating hypertension and congestive heart failure, it also has a unique effect on myocardial infarction.

Reference

[1]. Dal Bo, L., P. Mazzucchelli, and A. Marzo, Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Biomed Sci Appl, 2000. 749(2): p. 287-94.
[2]. Kalender, A.M., et al., Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model. J Brachial Plex Peripher Nerve Inj, 2009. 4: p. 6.
[3]. Frascarelli, S., et al., Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling. J Cardiovasc Pharmacol, 2009. 54(5): p. 456-63.