Zoliflodacin

• CAT Number: I010164
• CAS Number: 1620458-09-4
• Molecular Formula: C22H22FN5O7
• Molecular Weight: 487.44
• Purity: 98%
• Synonyms: ETX0914; ETX-0914; ETX 0914; AZD0914; AZD-0914; AZD 0914; Zoliflodacin; CAS#1620458-09-4.;(2R,4S,4aS)-11-fluoro-2,4-dimethyl-8-((S)-4-methyl-2-oxooxazolidin-3-yl)-1,2,4,4a-tetrahydro-2/’H,6H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5/’-
• Target: DNA gyrase inhibitor
• Solubility: Soluble in DMSO, not in water
• Appearance: Solid powder
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (4'R,6'S,7'S)-17'-fluoro-4',6'-dimethyl-13'-[(4S)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]spiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione
• InChI: InChI=1S/C22H22FN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/m0/s1
• InChIKey: ZSWMIFNWDQEXDT-ZESJGQACSA-N
• SMILES: CC1CN2C(C(O1)C)C3(CC4=CC5=C(C(=C42)F)ON=C5N6C(COC6=O)C)C(=O)NC(=O)NC3=O

Zoliflodacin (CAT: I010164) is a novel antibiotic belonging to the class of spiropyrimidinetriones. It specifically targets bacterial DNA gyrase, an essential enzyme involved in DNA replication and transcription, thereby inhibiting bacterial growth and replication. Zoliflodacin has demonstrated potent activity against various strains of Neisseria gonorrhoeae, including those resistant to traditional antibiotics such as fluoroquinolones. It is being investigated as a potential treatment for gonorrhea, a sexually transmitted infection that has become increasingly resistant to existing antibiotics.