Zoliflodacin

For research use only. Not for therapeutic Use.

  • CAT Number: I010164
  • CAS Number: 1620458-09-4
  • Molecular Formula: C22H22FN5O7
  • Molecular Weight: 487.44
  • Purity: 98%
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Zoliflodacin (Cat No.:I010164) is a novel antibiotic belonging to the class of spiropyrimidinetriones. It specifically targets bacterial DNA gyrase, an essential enzyme involved in DNA replication and transcription, thereby inhibiting bacterial growth and replication. Zoliflodacin has demonstrated potent activity against various strains of Neisseria gonorrhoeae, including those resistant to traditional antibiotics such as fluoroquinolones. It is being investigated as a potential treatment for gonorrhea, a sexually transmitted infection that has become increasingly resistant to existing antibiotics.


Catalog Number I010164
CAS Number 1620458-09-4
Synonyms

ETX0914; ETX-0914; ETX 0914; AZD0914; AZD-0914; AZD 0914; Zoliflodacin; CAS#1620458-09-4.;(2R,4S,4aS)-11-fluoro-2,4-dimethyl-8-((S)-4-methyl-2-oxooxazolidin-3-yl)-1,2,4,4a-tetrahydro-2/’H,6H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5/’-

Molecular Formula C22H22FN5O7
Purity 98%
Target Anti-infection
Solubility Soluble in DMSO, not in water
Appearance Solid powder
Storage 0 - 4 °C for short term, or -20 °C for long term
IUPAC Name (4'R,6'S,7'S)-17'-fluoro-4',6'-dimethyl-13'-[(4S)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]spiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione
InChI InChI=1S/C22H22FN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/m0/s1
InChIKey ZSWMIFNWDQEXDT-ZESJGQACSA-N
SMILES C[C@@H]1CN2[C@H]([C@@H](O1)C)C3(CC4=CC5=C(C(=C42)F)ON=C5N6[C@H](COC6=O)C)C(=O)NC(=O)NC3=O

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