For research use only. Not for therapeutic Use.
Zolmitriptan is a member of the triptan class agents with anti-migraine property. Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B expressed in intracranial arteries and 5_HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brain stem sensory nuclei. Receptor binding results in constriction of cranial vessels, reduction of the vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relief migraine headaches by inhibition pro-inflammatory neuropeptide release.
| Catalog Number | A001095 |
| CAS Number | 139264-17-8 |
| Synonyms | NA |
| Molecular Formula | C16H21N3O2 |
| Purity | ≥95% |
| Target | 5-HT Receptor |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | 3 years -20C powder |
| InChIKey | ULSDMUVEXKOYBU-ZDUSSCGKSA-N |
| Reference | </br>1:Microneedle-assisted transdermal delivery of Zolmitriptan: effect of microneedle geometry, in vitro permeation experiments, scaling analyses and numerical simulations. Uppuluri CT, Devineni J, Han T, Nayak A, Nair KJ, Whiteside BR, Das DB, Nalluri BN.Drug Dev Ind Pharm. 2017 Apr 20:1-12. doi: 10.1080/03639045.2017.1313862. [Epub ahead of print] PMID: 28375038 </br>2:Formulation development and evaluation of zolmitriptan oral soluble films using 2<sup>2</sup> factorial designs. Koteswari P, Sravanthi GP, Mounika M, Mohammed Rafi SK, Nirosha K.Int J Pharm Investig. 2016 Oct-Dec;6(4):201-206. doi: 10.4103/2230-973X.195927. PMID: 28123989 Free PMC Article</br>3:Bursting deep dorsal horn neurons: the pharmacological target for the antispastic effects of zolmitriptan? Carlsen EM, Rasmussen R.J Neurophysiol. 2017 May 1;117(5):1841-1843. doi: 10.1152/jn.00880.2016. Epub 2016 Dec 14. PMID: 27974452 </br>4:<sup>99m</sup>Tc-zolmitriptan: radiolabeling, molecular modeling, biodistribution and gamma scintigraphy as a hopeful radiopharmaceutical for lung nuclear imaging. Rashed HM, Marzook FA, Farag H.Radiol Med. 2016 Dec;121(12):935-943. Epub 2016 Sep 1. PMID: 27586132 </br>5:Intranasal Eutectic Powder of Zolmitriptan with Enhanced Bioavailability in the Rat Brain. Khan T, Ranjan R, Dogra Y, Pandya SM, Shafi H, Singh SK, Yadav PN, Misra A.Mol Pharm. 2016 Sep 6;13(9):3234-40. doi: 10.1021/acs.molpharmaceut.6b00453. Epub 2016 Aug 19. PMID: 27518323 </br>6:Delayed absorption of many (paracetamol, aspirin, other NSAIDs and zolmitriptan) but not all (sumatriptan, rizatriptan) drugs during migraine attacks and most likely normal gastric emptying outside attacks. A review. Tfelt-Hansen PC.Cephalalgia. 2016 Jun 20. pii: 0333102416644745. [Epub ahead of print] Review. PMID: 27330004 </br>7:Efficacy and tolerability of zolmitriptan nasal spray for the treatment of acute migraine in adolescents: Results of a randomized, double-blind, multi-center, parallel-group study (TEENZ). Winner P, Farkas V, Štillová H, Woodruff B, Liss C, Lillieborg S, Raines S; TEENZ Study Group..Headache. 2016 Jul;56(7):1107-19. doi: 10.1111/head.12859. Epub 2016 Jun 22. PMID: 27329280 </br>8:Trans-nasal zolmitriptan novasomes: in-vitro preparation, optimization and in-vivo evaluation of brain targeting efficiency. Abd-Elal RM, Shamma RN, Rashed HM, Bendas ER.Drug Deliv. 2016 Nov;23(9):3374-3386. Epub 2016 May 17. PMID: 27128792 </br>9:Intranasal Pharmacokinetic Data for Triptans Such as Sumatriptan and Zolmitriptan Can Render Area Under the Curve (AUC) Predictions for the Oral Route: Strategy Development and Application. Srinivas NR, Syed M.J Pain Palliat Care Pharmacother. 2016;30(1):13-24. doi: 10.3109/15360288.2015.1124165. Epub 2016 Feb 11. PMID: 26865407 </br>10:Poloxamer 407-based intranasal thermoreversible gel of zolmitriptan-loaded nanoethosomes: formulation, optimization, evaluation and permeation studies. Shelke S, Shahi S, Jalalpure S, Dhamecha D.J Liposome Res. 2016 Dec;26(4):313-23. doi: 10.3109/08982104.2015.1132232. Epub 2016 Jan 12. PMID: 26758957 |
