For research use only. Not for therapeutic Use.
SPB（Cat No.:I013181） is an ADC (antibody-drug conjugate) drug conjugate that consists of Xanthotoxol linked to an antibody. This conjugate exhibits anti-inflammatory activity, making it a potential therapeutic agent for inflammatory conditions. By combining the targeting capabilities of the antibody with the anti-inflammatory properties of Xanthotoxol, SPB aims to provide targeted delivery of the drug to specific sites of inflammation, potentially reducing off-target effects.
| Catalog Number | I013181 |
| CAS Number | 858128-57-1 |
| Synonyms | SPB |
| Molecular Formula | C₁₉H₁₅NO₈ |
| Purity | ≥95% |
| Target | Others |
| Solubility | DMSO |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 4-(7-oxofuro[3,2-g]chromen-9-yl)oxybutanoate |
| InChI | InChI=1S/C19H15NO8/c21-13-4-5-14(22)20(13)28-16(24)2-1-8-25-19-17-12(7-9-26-17)10-11-3-6-15(23)27-18(11)19/h3,6-7,9-10H,1-2,4-5,8H2 |
| InChIKey | ZOMXGWWLJXRQKZ-UHFFFAOYSA-N |
| SMILES | C1CC(=O)N(C1=O)OC(=O)CCCOC2=C3C(=CC4=C2OC=C4)C=CC(=O)O3 |
| Reference | [1]. Xu Y, et al. DIFFERENTIAL SUSCEPTIBILITY OF HUMAN SP-B GENETIC VARIANTS ON LUNG INJURY CAUSED BY BACTERIAL PNEUMONIA AND THE EFFECT OF A CHEMICALLY MODIFIED CURCUMIN. Shock. 2016 Apr;45(4):375-84.<br>[2]. Sato A, et al. SP-B and SP-C containing new synthetic surfactant for treatment of extremely immature lamb lung. PLoS One. 2012;7(7):e39392. |
