For research use only. Not for therapeutic Use.
Zoniporide dihydrochloride (Cat.No:I010614) is a sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (K<sub>i</sub> values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent <sup>22</sup>Na<sup>+</sup> uptake <em>in vitro</em> (IC<sub>50</sub> = 14 nM) and provides cardioprotection from myocardial ischemic injury <em>in vivo</em> (EC<sub>50</sub> = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.
| Catalog Number | I010614 |
| CAS Number | 241799-10-0 |
| Synonyms | Alternative Name: CP 597396 |
| Molecular Formula | C17H18Cl2N6O |
| Purity | ≥95% |
| Target | Na+/Ca2+ Exchanger |
| Solubility | Soluble to 10 mM in water and to 100 mM in DMSO |
| Storage | Store at -20C |
| IUPAC Name | 5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide;dihydrochloride |
| InChI | InChI=1S/C17H16N6O.2ClH/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);2*1H |
| InChIKey | ARZNPJAGKWHEHT-UHFFFAOYSA-N |
| SMILES | C1CC1C2=C(C=NN2C3=CC=CC4=C3C=CC=N4)C(=O)N=C(N)N.Cl.Cl |
