Zoniporide HCl

• CAT Number: I010167
• CAS Number: 241800-97-5
• Molecular Formula: C17H17ClN6O
• Molecular Weight: 356.81
• Purity: ≥95%
• Synonyms: CP-597396; CP 597396; CP597396; CP-597,396; CP 597,396; CP597,396; Zoniporide HCl.;N-carbamimidoyl-5-cyclopropyl-1-(quinolin-5-yl)-1H-pyrazole-4-carboxamide hydrochloride
• Target: Na+/H+ Exchanger (NHE)
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide;hydrochloride
• InChI: InChI=1S/C17H16N6O.ClH/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H
• InChIKey: JTEXNYIOROVPIR-UHFFFAOYSA-N
• SMILES: O=C(C1=C(C2CC2)N(C3=C4C=CC=NC4=CC=C3)N=C1)NC(N)=N.[H]Cl

Zoniporide HCl(CAT: I010167) is a potent and selective inhibitor of Na⁺/H⁺ exchanger isoform 1 (NHE-1), a membrane protein involved in regulating intracellular pH and ion homeostasis. By inhibiting NHE-1, Zoniporide reduces intracellular sodium and calcium overload, offering cardioprotective effects in conditions such as ischemia-reperfusion injury. It is widely studied in cardiovascular pharmacology for its potential in treating myocardial infarction, heart failure, and other ischemic conditions. Zoniporide HCl provides valuable insights into the role of NHE-1 in cellular physiology and supports the development of targeted therapies for cardiovascular diseases associated with ionic dysregulation.