For research use only. Not for therapeutic Use.
Zopiclone is a nonbenzodiazepine hypnotic agent used in the treatment of insomnia. It is a cyclopyrrolone, which increases the normal transmission of the neurotransmitter GABA in the central nervous system, as benzodiazepines do, but in a different way. As zopiclone is sedating, it is marketed as a sleeping pill. It works by causing a depression or tranquilization of the central nervous system.
| Catalog Number | R006811 |
| CAS Number | 43200-80-2 |
| Synonyms | 4-Methyl-1-piperazine-carboxylic Acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl Ester; RP-27267; Amoban; Imovane; Limovan; Sopivan; Ximovan; Zimovane; |
| Molecular Formula | C17H17ClN6O3 |
| Purity | ≥95% |
| Storage | -20°C |
| InChIKey | GBBSUAFBMRNDJC-UHFFFAOYSA-N |
| Reference | </br>1:Zopiclone overdose and flumazenil rescue. Cimolai N.CMAJ. 2017 Apr 24;189(16):E613. doi: 10.1503/cmaj.732933. No abstract available. PMID: 28438958 </br>2:First derivative spectrofluorimetric determination of zopiclone and its degradation product, 2-amino-5-chloropyridine, in pharmaceutical formulations with preliminary tool in biological fluids for clinical evidence of zopiclone intake. Al-Attas AS, Nasr JJ, Shalan S, Belal F.Spectrochim Acta A Mol Biomol Spectrosc. 2017 Jun 15;181:148-152. doi: 10.1016/j.saa.2017.03.036. Epub 2017 Mar 18. PMID: 28359903 </br>3:Zopiclone Use and Risk of Fractures in Older People: Population-Based Study. Nishtala PS, Chyou TY.J Am Med Dir Assoc. 2017 Apr 1;18(4):368.e1-368.e8. doi: 10.1016/j.jamda.2016.12.085. Epub 2017 Feb 22. PMID: 28236610 </br>4:Paradoxical insomnia in a patient taking zopiclone. Abba-Aji A, Bardoloi P.BMJ Case Rep. 2017 Jan 19;2017. pii: bcr2016217335. doi: 10.1136/bcr-2016-217335. PMID: 28104722 </br>5:Evaluation of In Vitro Cytochrome P450 Inhibition and In Vitro Fate of Structurally Diverse N-Oxide Metabolites: Case Studies with Clozapine, Levofloxacin, Roflumilast, Voriconazole and Zopiclone. Giri P, Naidu S, Patel N, Patel H, Srinivas NR.Eur J Drug Metab Pharmacokinet. 2016 Nov 16. [Epub ahead of print] PMID: 27853934 </br>6:Reversal of a Suspected Paradoxical Reaction to Zopiclone with Flumazenil. Jordahn Z, Andersen C, Roust Aaberg AM, Christian Pott F.Case Rep Crit Care. 2016;2016:3185873. doi: 10.1155/2016/3185873. Epub 2016 Sep 8. PMID: 27672456 Free PMC Article</br>7:Simultaneous analysis method for GHB, ketamine, norketamine, phenobarbital, thiopental, zolpidem, zopiclone and phenytoin in urine, using C18 poroshell column. Anilanmert B, Çavuş F, Narin I, Cengiz S, Sertler Ş, Özdemir AA, Açikkol M.J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:230-41. doi: 10.1016/j.jchromb.2016.03.040. Epub 2016 Apr 9. PMID: 27107852 </br>8:GP is suspended after prescribing zopiclone for patient to give to neighbours. Dyer C.BMJ. 2016 Feb 15;352:i921. doi: 10.1136/bmj.i921. No abstract available. PMID: 26880096 </br>9:Eszopiclone versus zopiclone in the treatment of insomnia. Pinto Jr LR, Bittencourt LR, Treptow EC, Braga LR, Tufik S.Clinics (Sao Paulo). 2016 Jan;71(1):5-9. doi: 10.6061/clinics/2016(01)02. PMID: 26872077 Free PMC Article</br>10:Zopiclone Increases the Arousal Threshold without Impairing Genioglossus Activity in Obstructive Sleep Apnea. Carter SG, Berger MS, Carberry JC, Bilston LE, Butler JE, Tong BK, Martins RT, Fisher LP, McKenzie DK, Grunstein RR, Eckert DJ.Sleep. 2016 Apr 1;39(4):757-66. doi: 10.5665/sleep.5622. PMID: 26715227 Free PMC Article |
