(-)-Zuonin A

• CAT Number: I044917
• CAS Number: 84709-25-1
• Molecular Formula: C20H20O5
• Molecular Weight: 340.37
• Purity: ≥95%
• Synonyms: 5-[(2S,3R,4S,5S)-5-(1,3-benzodioxol-5-yl)-3,4-dimethyloxolan-2-yl]-1,3-benzodioxole
• InChI: InChI=1S/C20H20O5/c1-11-12(2)20(14-4-6-16-18(8-14)24-10-22-16)25-19(11)13-3-5-15-17(7-13)23-9-21-15/h3-8,11-12,19-20H,9-10H2,1-2H3/t11-,12+,19-,20-/m0/s1
• InChIKey: QFUXQRHAJWXPGP-YLYZPZNOSA-N
• SMILES: CC1C(C(OC1C2=CC3=C(C=C2)OCO3)C4=CC5=C(C=C4)OCO5)C

(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1].
(−)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs[1].
(−)-zuonin A inhibits the activation and phosphorylation of JNK by MKK4 and MKK7[1].

Reference

[1]. Tamer S. Kaoud, et al. Manipulating JNK Signaling with (−)-zuonin A. ACS Chem Biol. 2012 Nov 16; 7(11): 1873–1883.
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