For research use only. Not for therapeutic Use.
ZYF0033（Cat No.:I043899）is a selective small molecule inhibitor targeting the protein SYNJ2 (synaptojanin 2), a phosphatase involved in membrane trafficking and endocytic recycling. SYNJ2 plays a critical role in regulating synaptic vesicle recycling and maintaining cellular homeostasis. By inhibiting SYNJ2, ZYF0033 disrupts the recycling process, which may be beneficial in treating diseases associated with dysfunctional endocytosis and vesicle trafficking, such as neurodegenerative disorders and certain cancers. Preclinical studies suggest that ZYF0033 could be a promising therapeutic candidate for modulating synaptic function and cellular trafficking pathways.
| CAS Number | 2380300-79-6 |
| Synonyms | 4-[3-[[2-amino-5-[2-(1-methylpiperidin-4-yl)-1,3-thiazol-5-yl]pyridin-3-yl]oxymethyl]phenyl]-2-methylbut-3-yn-2-ol |
| Molecular Formula | C26H30N4O2S |
| Purity | ≥95% |
| IUPAC Name | 4-[3-[[2-amino-5-[2-(1-methylpiperidin-4-yl)-1,3-thiazol-5-yl]pyridin-3-yl]oxymethyl]phenyl]-2-methylbut-3-yn-2-ol |
| InChI | InChI=1S/C26H30N4O2S/c1-26(2,31)10-7-18-5-4-6-19(13-18)17-32-22-14-21(15-28-24(22)27)23-16-29-25(33-23)20-8-11-30(3)12-9-20/h4-6,13-16,20,31H,8-9,11-12,17H2,1-3H3,(H2,27,28) |
| InChIKey | BJNWUKRWOQERPQ-UHFFFAOYSA-N |
| SMILES | CC(C)(C#CC1=CC=CC(=C1)COC2=C(N=CC(=C2)C3=CN=C(S3)C4CCN(CC4)C)N)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
