For research use only. Not for therapeutic Use.
ZYF0033 is effective in inhibiting hematopoietic progenitor cells HPK1, basically inhibiting MBP protein oxidation IC50 10 nM . ZYF0033 promotes anti-cancer immune response, lowers SLP76 (acid 376) oxidation. ZYF0033 Suppression 4T-1 Small mouse model with the same underlying cause, medium bulge growth length expansion DC, NK 细细和 CD107a+ CD8+ T Cells, PD-1+CD8+ T Cells, TIM-3+CD8+ T Cells LAG3< sup>+CD8+ T Cellular immersion decreases.
ZYF0033 (100 nM; 24 h) reduces phosphorylation of SLP76 (serine 376), a key biomarker of T cell and HPK1 activation. ZYF0033 causes HPK1 inhibition, increased proliferation of CD4+ and CD8+ T cells, and IFN-γ secretion[1].
The maximum tolerated dose of ZYF0033 exceeds 50 mg/kg (daily; po) and exceeds 120 mg/kg in a 6-day toxicity study. In the 4T-1 syngeneic mouse model, ZYF0033 regulates immune cell subsets, increases DC and NK cell infiltration, and promotes anti-cancer immune response[1].
| Catalog Number | I043899 |
| CAS Number | 2380300-79-6 |
| Synonyms | 4-[3-[[2-amino-5-[2-(1-methylpiperidin-4-yl)-1,3-thiazol-5-yl]pyridin-3-yl]oxymethyl]phenyl]-2-methylbut-3-yn-2-ol |
| Molecular Formula | C26H30N4O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C26H30N4O2S/c1-26(2,31)10-7-18-5-4-6-19(13-18)17-32-22-14-21(15-28-24(22)27)23-16-29-25(33-23)20-8-11-30(3)12-9-20/h4-6,13-16,20,31H,8-9,11-12,17H2,1-3H3,(H2,27,28) |
| InChIKey | BJNWUKRWOQERPQ-UHFFFAOYSA-N |
| SMILES | CC(C)(C#CC1=CC=CC(=C1)COC2=C(N=CC(=C2)C3=CN=C(S3)C4CCN(CC4)C)N)O |
| Reference | [1]. Si J, et al. Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies. Cancer Cell. 2020 Oct 12;38(4):551-566.e11. [2]. Jingwen Si, et al. Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies. Cancer Cell. 2020 Oct 12;38(4):551-566.e11. |
