ZYZ-488

• CAT Number: I019134
• CAS Number: 1470302-79-4
• Molecular Formula: C₂₀H₂₉N₃O₁₁
• Molecular Weight: 487.46
• Purity: ≥95%
• Target: Caspase
• IUPAC Name: (2S,3S,4S,5R,6S)-6-[4-[4-(diaminomethylideneamino)butoxycarbonyl]-2,6-dimethoxyphenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
• InChI: InChI=1S/C20H29N3O11/c1-30-10-7-9(18(29)32-6-4-3-5-23-20(21)22)8-11(31-2)15(10)33-19-14(26)12(24)13(25)16(34-19)17(27)28/h7-8,12-14,16,19,24-26H,3-6H2,1-2H3,(H,27,28)(H4,21,22,23)/t12-,13-,14+,16-,19+/m0/s1
• InChIKey: PVTAIJDQJJZCJP-WXZWTWHISA-N
• SMILES: COC1=CC(=CC(=C1O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C(=O)O)O)O)O)OC)C(=O)OCCCCN=C(N)N

ZYZ-488 (Cat No.:I019134) pertains to its potential as an apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 has been shown to inhibit the activation of procaspase-9 and procaspase-3, which are binding proteins involved in the apoptotic pathway. In hypoxic H9c2 cells, ZYZ-488 has demonstrated a decrease in apoptosis by inhibiting the Apaf-1-mediated activation of procaspase-9 and procaspase-3. Additionally, ZYZ-488 has shown a protective effect against myocardial apoptosis, reducing myocardial enzyme release, inhibiting cardiomyocyte apoptosis, and suppressing the activation of caspases. This suggests that ZYZ-488 may have potential therapeutic implications for conditions involving apoptotic pathways and myocardial health.

Reference

[1]. Wang Y, et al. The discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: synthesis, activity and target identification. Sci Rep. 2016 Jul 22;6:29820.