For research use only. Not for therapeutic Use.
ZZW-115 hydrochloride (CAT: I009677) is a potent inhibitor of the protein NUPR1, with a Kd (dissociation constant) of 2.1 μM. It has demonstrated anticancer activity by inducing tumor cell death through necroptosis and apoptosis. In various cancer cell lines, ZZW-115 hydrochloride effectively kills cancer cells with IC50 values ranging from 0.84 μM to 7.75 μM. Treatment with ZZW-115 hydrochloride leads to decreased ATP production, increased ROS (reactive oxygen species) generation, and activation of caspase 3/7, indicating both necrotic and apoptotic effects. In vivo, studies have shown that ZZW-115 hydrochloride inhibits the growth of pancreatic xenografted tumors and significantly reduces tumor size.
| Catalog Number | I009677 |
| CAS Number | 10122-45-9 |
| Molecular Formula | C₂₄H₃₄Cl₃F₃N₄S |
| Purity | ≥95% |
| Target | Apoptosis |
| Reference | [1]. Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129(6):2500-2513. Published 2019 Mar 28.<br>[2]. Santofimia-Castaño P, et al. Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma. Cells. 2019;8(11):1453. Published 2019 Nov 17. |
