Recombinant Guinea Pig Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA4) Protein (His), Active

• Purity: Greater than 90% as determined by SDS-PAGE.
• Host Species: Cavia porcellus (Guinea pig)
• Accession: H0VUB1
• Gene: CTLA4
• CAT.NO: B000277
• Expression Systems: Yeast
• Product Name: Recombinant Guinea Pig Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA4) Protein (His), Active
• Endotoxin: Less than 1.0 EU/μg as determined by LAL method.
• Protein Expression Range: 37-161aa
• Tag: C-6His
• Molecular Mass: 14.1 kDa
• Form: Liquid
• Buffer: 0.2 μm filtered 1xPBS, pH 7.4
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.; 2. Avoid repeated freeze-thaw cycles.; 3. Store working aliquots at 4°C for up to one week.; 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
• Bioactivity: The ED50 as determined by its ability to bind Mouse B7-1 in functional ELISA is less than 0.4 ug/ml.
• Research Area: Immunology
• Protein Length: Partial

CTLA4 is an inhibitory receptor that serves as a key negative regulator of T-cell responses. It binds to the B7 family ligands, CD80 and CD86, with a significantly higher affinity than the stimulatory coreceptor CD28, which also interacts with these ligands. This strong binding allows CTLA4 to effectively dampen T-cell activation and prevent excessive immune responses. By inhibiting signals that would normally activate T-cells, CTLA4 helps maintain immune system balance and prevents autoimmunity, ensuring that the immune response remains controlled and targeted, without causing harm to the body’s own tissues.