The 5-hydroxytryptamine receptor 1A (HTR1A) is a G-protein coupled receptor (GPCR) for serotonin (5-hydroxytryptamine) and serves as a target for various drugs and psychoactive substances. Ligand binding induces a conformational change that activates guanine nucleotide-binding proteins (G proteins), modulating downstream effectors such as adenylate cyclase. HTR1A is primarily coupled to G(i)/G(o) alpha proteins, mediating inhibitory neurotransmission by reducing adenylate cyclase activity and activating a phosphatidylinositol-calcium second messenger system, which facilitates the release of Ca2+from
intracellular stores.
The receptor plays a key role in regulating serotonin release and maintaining dopamine and serotonin balance in the brain, influencing neural activity, mood, and behavior. It is involved in the brain’s response to anxiogenic stimuli, contributing to the modulation of anxiety and emotional states.
Beta-arrestin proteins regulate HTR1A signaling by mediating receptor desensitization and resensitization, ensuring precise control of neurotransmission. Through its broad functional roles, HTR1A affects critical physiological and psychological processes, making it a significant target in the study and treatment of mood disorders, anxiety, and other serotonin-related conditions.
| Product Name | Recombinant Human 5HT1A Receptor Protein |
| Accession | P08908 |
| Host Species | Human |
| Gene | HTR1A |
| Source | Wheat germ |
