This enzyme catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine, playing a critical role in purine metabolism and maintaining adenosine homeostasis. By modulating extracellular adenosine levels, it indirectly influences cellular signaling pathways. It acts as a positive regulator of T-cell coactivation through interaction with DPP4, which also facilitates lymphocyte-epithelial cell adhesion.
The enzyme enhances dendritic cell immunogenicity by influencing the expression of costimulatory molecules and the secretion of cytokines and chemokines. It promotes CD4+ T-cell differentiation and proliferation, supporting adaptive immunity. Additionally, it positively modulates adenosine receptors ADORA1 and ADORA2A, increasing their ligand affinity via conformational changes.
Beyond immune functions, it stimulates plasminogen activation and plays roles in male fertility and early postimplantation embryonic development. It also deaminates cordycepin (3′-deoxyadenosine), a fungal natural product with antitumor, antibacterial, antifungal, antiviral, and immune-regulating properties. These diverse roles highlight its importance in metabolism, immunity, reproduction, and therapeutic applications.
| Product Name | Recombinant Human Adenosine Deaminase / ADA Protein (His Tag) |
| Accession | P00813 |
| Host Species | Human |
| Gene | ADA |
| Source | Baculovirus insect cells |
