This protein binds water, ions (Ca2+^2+, Na+^+, K+^+), fatty acids, hormones, bilirubin, and various drugs. Its primary role is regulating the colloidal osmotic pressure of blood. Additionally, it serves as the major plasma zinc transporter, binding approximately 80% of plasma zinc, and is a key calcium and magnesium transporter, binding about 45% of circulating Ca2+^2+ and Mg2+^2+.
The protein potentially has multiple calcium-binding sites and may bind calcium non-specifically. A shared binding site at Asp-273 for both zinc and calcium suggests a crosstalk between their transport in plasma. The binding affinity rank order is zinc > calcium > magnesium.
It also binds the bacterial siderophore enterobactin, inhibiting enterobactin-mediated iron uptake from ferric transferrin by E. coli. This action may limit iron utilization and the growth of enteric bacteria like E. coli, highlighting a role in host defense against pathogens.
| Product Name | Recombinant Human Albumin Protein |
| Accession | P02768 |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Host Species | Human |
| Gene | Albumin |
| Source | P.Pichia |
| Protein Expression Range | Asp25-Leu609 |
| Tag | Tag free |
| Molecular Mass | 66.5 KDa |
| Buffer | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Storage | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
