This enzyme catalyzes the conversion of citrate into oxaloacetate and acetyl-CoA, a critical step in cellular metabolism. Acetyl-CoA serves as a central substrate for de novo synthesis of cholesterol and fatty acids, linking the citric acid cycle to lipid biosynthesis. By facilitating this reaction, the enzyme plays a key role in energy homeostasis and the production of essential biomolecules necessary for cell growth, membrane formation, and metabolic regulation. Its activity underscores its importance in maintaining lipid and cholesterol synthesis pathways.
| Product Name | Recombinant Human Atp-Citrate Synthase (ACLY) Protein (His-SUMO) |
| Accession | P53396 |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Host Species | Human |
| Gene | ACLY |
| Source | E.coli |
| Protein Expression Range | 4-265aa |
| Tag | N-6His-SUMO |
| Molecular Mass | 45.5kDa |
| Form | Liquid or Lyophilized powder |
| Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Storage | 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C. |
