Recombinant Human B-Lymphocyte Antigen Cd19 (CD19) Protein (hFc), Active

• Purity: Greater than 80% as determined by SDS-PAGE.
• Host Species: Homo sapiens (Human)
• Accession: P15391
• Gene: CD19
• CAT.NO: B000262
• Expression Systems: Mammalian cell
• Product Name: Recombinant Human B-Lymphocyte Antigen Cd19 (CD19) Protein (hFc), Active
• Endotoxin: Less than 1.0 EU/μg as determined by LAL method.
• Protein Expression Range: 20-291aa
• Tag: C-hFc
• Molecular Mass: 57.3 kDa
• Form: Lyophilized powder
• Buffer: Lyophilized from a 0.2 μm filtered 20mM PB, 150mM NaCl, pH 7.4
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.; 2. Avoid repeated freeze-thaw cycles.; 3. Store working aliquots at 4°C for up to one week.; 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
• Bioactivity: The ED50 as determined by its ability to binding CD19 used funtional ELISA is less than 20 ug/ml
• Research Area: Immunology
• Protein Length: Extracellular Domain

This protein functions as a coreceptor for the B-cell antigen receptor (BCR) complex on B-lymphocytes. It lowers the activation threshold for downstream signaling pathways, enhancing B-cell responses to antigens. It activates signaling pathways that lead to phosphatidylinositol 3-kinase activation and the mobilization of intracellular Ca2+ stores. While not essential for early B-cell differentiation in the bone marrow, it is required for the normal differentiation of B-1 cells. It plays a critical role in B-cell differentiation and proliferation in response to antigen challenges, maintaining normal serum immunoglobulin levels and enabling the production of high-affinity antibodies.