Recombinant Human Calcitonin gene-related peptide type 1 receptor (CALCRL), partial

• Purity: >85% (SDS-PAGE)
• Host Species: Homo sapiens (Human)
• Accession: Q16602
• Gene: CALCRL
• CAT.NO: B000131
• Expression Systems: E.coli In Vivo Biotinylation in E.coli Yeast Baculovirus Mammalian cell
• Product Name: Recombinant Human Calcitonin gene-related peptide type 1 receptor (CALCRL), partial
• Source: E.coli;In Vivo Biotinylation in E.coli;Yeast;Baculovirus;Mammalian cell
• Tag: Tag type will be determined during the manufacturing process.
• Form: Lyophilized powder
• Buffer: Tris/PBS-based buffer, 6% Trehalose.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Alternative Names: CALCRL; CGRPR; Calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; Calcitonin receptor-like receptor
• Protein Length: Partial
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Shelf Life: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.; Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

This G protein-coupled receptor’s specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). When paired with RAMP1, it forms the receptor complex for calcitonin gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. In combination with RAMP2 or RAMP3, it functions as a receptor complex for adrenomedullin (ADM and ADM2). Ligand binding induces a conformational change that activates signaling through guanine nucleotide-binding proteins (G proteins), modulating downstream effectors. This signaling pathway activates the cAMP-dependent cascade, influencing various physiological processes and cellular responses associated with these ligands.