Recombinant Human Casein Kinase I Isoform Epsilon (CSNK1E) Protein (His)

• Purity: Greater than 90% as determined by SDS-PAGE.
• Host Species: Human
• Accession: P49674
• Gene: CSNK1E
• CAT.NO: B000026
• Expression Systems: E.coli
• Product Name: Recombinant Human Casein Kinase I Isoform Epsilon (CSNK1E) Protein (His)
• Protein Expression Range: 1-416aa
• Tag: N-6His
• Molecular Mass: 51.3kDa
• Form: Liquid or Lyophilized powder
• Buffer: Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Storage: 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C.

Casein kinases are characterized by their ability to phosphorylate acidic proteins like caseins. They play a role in Wnt signaling by phosphorylating key components such as DVL1, DVL2, and NEDD9/HEF1 (by similarity).
A central regulator of the circadian clock, casein kinase balances with PP1 to influence the circadian period length by controlling the phosphorylation, nuclear transport, and degradation of PER1 and PER2, thereby regulating the speed and rhythmicity of the circadian cycle (by similarity).
Additionally, it inhibits cytokine-induced granulocytic differentiation, highlighting its involvement in cellular signaling and differentiation processes. These multifunctional roles underline its importance in regulating circadian rhythm, cell signaling, and physiological processes.