This enzyme catalyzes the O-methylation of catecholamine neurotransmitters and catechol hormones, leading to their inactivation. It plays a crucial role in regulating neurotransmitter levels and modulating physiological responses. Additionally, it shortens the biological half-lives of neuroactive drugs, such as L-DOPA, alpha-methyl DOPA, and isoproterenol, by facilitating their metabolic breakdown. Through these actions, the enzyme is essential for maintaining neurotransmitter homeostasis and influencing the pharmacokinetics of certain medications, making it a critical player in both neural function and drug metabolism.
| Product Name | Recombinant Human Catechol O-Methyltransferase (COMT) Protein (His) |
| Accession | P21964 |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Host Species | Human |
| Gene | COMT |
| Source | E.coli |
| Protein Expression Range | 52-271aa |
| Tag | N-6His |
| Molecular Mass | 28.3kDa |
| Form | Liquid or Lyophilized powder |
| Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Storage | 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C. |
