This receptor on immune cells delivers either stimulatory or inhibitory signals that regulate cell activation and differentiation. It exists as both a GPI-anchored and a transmembrane form, each likely initiating distinct signaling pathways through phosphoinositol 3-kinase in NK cells and through LCK and CD247/CD3 zeta chain in T cells. Serving as a receptor for classical and non-classical MHC class I molecules, it triggers NK cell cytotoxicity in response to HLA-C during viral infection and provides a costimulatory signal to activated/memory CD8+ T cells. However, during chronic infection, it may inhibit TCR signaling, contributing to T cell exhaustion.
| Product Name | Recombinant Human Cd160 Antigen (CD160) Protein (His), Active |
| Accession | O95971 |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Host Species | Homo sapiens (Human) |
| Gene | CD160 |
| Source | Mammalian cell |
| Protein Expression Range | 27-159aa |
| Tag | C-6His |
| Molecular Mass | 15.8 kDa |
| Form | Lyophilized powder |
| Buffer | Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.4 |
| Storage | 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Bioactivity | The ED50 as determined by its ability to bind Mouse TNFRSF14 in functional ELISA is less than 50 ug/ml. |
| Research Area | Immunology |
| Protein Length | Full Length of Mature Protein |
