Recombinant Human Cytochrome P450 2B6/CYP2B6 Protein

  • Host Species: Human
  • Accession: P20813
  • Gene: CYP2B6
  • CAT.NO: B000056
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This cytochrome P450 monooxygenase is involved in the metabolism of endocannabinoids, steroids, and xenobiotics. It utilizes molecular oxygen to insert one oxygen atom into substrates and reduces the second to water, using electrons supplied by NADPH through cytochrome P450 reductase. The enzyme catalyzes the epoxidation of arachidonoylethanolamide (anandamide), producing 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid signaling pathways.
It hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2, influencing steroid metabolism. Additionally, it participates in the oxidative metabolism of xenobiotics, such as plant-derived lipids and pharmaceutical drugs. The enzyme also functions as a 1,4-cineole 2-exo-monooxygenase, demonstrating its diverse catalytic roles. By impacting endocannabinoid signaling, steroid metabolism, and xenobiotic detoxification, this monooxygenase plays a critical role in maintaining metabolic and physiological homeostasis.

Product Name Recombinant Human Cytochrome P450 2B6/CYP2B6 Protein
Accession P20813
Host Species Human
Gene CYP2B6
Source Wheat germ

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