This receptor binds endothelin-1 (ET-1) and mediates its effects through G proteins, which activate the phosphatidylinositol-calcium second messenger system. It plays a central role in vasoconstriction and other physiological processes regulated by endothelins. The receptor demonstrates a specific binding affinity, with a rank order of ET-1 > ET-2 >> ET-3. As a critical mediator of endothelin-1’s potent actions, this receptor is involved in cardiovascular regulation, smooth muscle contraction, and cell proliferation, making it a significant target for therapeutic strategies addressing hypertension, pulmonary arterial hypertension, and other vascular disorders.
| Product Name | Recombinant Human Endothelin-1 Receptor (EDNRA) Protein (His) |
| Accession | P25101 |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Host Species | Human |
| Gene | EDNRA |
| Source | Yeast |
| Protein Expression Range | 21-80aa |
| Tag | N-6His |
| Molecular Mass | 8.8kDa |
| Form | Liquid or Lyophilized powder |
| Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Storage | 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C. |
