This nuclear hormone receptor binds estrogens with an affinity comparable to ESR1/ER-alpha and regulates the expression of reporter genes with estrogen response elements (ERE) in an estrogen-dependent manner. However, it lacks effective ligand-binding capability and exhibits minimal or no ERE binding activity, leading to significantly reduced ligand-dependent transactivation functionality. This unique characteristic limits its role in traditional estrogen signaling pathways while potentially influencing other estrogen-related cellular processes through alternative mechanisms or interactions.
| Product Name | Recombinant Human Estrogen Receptor Beta (ESR2) Protein (His) |
| Accession | Q92731 |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Host Species | Human |
| Gene | ESR2 |
| Source | Yeast |
| Protein Expression Range | 2-530aa |
| Tag | N-6His |
| Molecular Mass | 61.1kDa |
| Form | Liquid or Lyophilized powder |
| Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Storage | 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C. |
