Tyrosine-protein kinase FGFR2 serves as a cell-surface receptor for fibroblast growth factors, regulating cell proliferation, differentiation, migration, and apoptosis. It is essential for embryonic development, including proper embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin formation. FGFR2 promotes keratinocyte and immature osteoblast proliferation but induces apoptosis in differentiated osteoblasts, playing a critical role in skeletal development and osteoblast regulation.
FGFR2 phosphorylates PLCG1, FRS2, and PAK4, activating multiple signaling pathways upon ligand binding. PLCG1 activation generates diacylglycerol and inositol 1,4,5-trisphosphate, while FRS2 phosphorylation recruits GRB2, GAB1, PIK3R1, and SOS1, leading to activation of RAS, MAPK/ERK, and AKT1 pathways. FGFR2 signaling is tightly regulated through ubiquitination, internalization, and degradation. Mutations causing constitutive activation or impaired inactivation result in aberrant signaling, linked to developmental disorders and cancer. Overexpression of FGFR2 drives STAT1 activation, highlighting its role in pathological signaling when dysregulated.
| Product Name | Recombinant Human FGFR2IIIc Protein (C-Fc) |
| Accession | P21802 |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Host Species | Human |
| Gene | FGFR2IIIc |
| Source | Human Cells |
| Protein Expression Range | Arg22-Glu377 |
| Tag | C-Fc |
| Molecular Mass | 66.5 KDa |
| Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Storage | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
