Recombinant Human Fibroblast Growth Factor Receptor 1 (FGFR1) Protein (His)

• Purity: Greater than 90% as determined by SDS-PAGE.
• Host Species: Human
• Accession: P11362
• Gene: FGFR1
• CAT.NO: B000067
• Product Name: Recombinant Human Fibroblast Growth Factor Receptor 1 (FGFR1) Protein (His)
• Source: Mammalian cell
• Protein Expression Range: 22-376aa
• Tag: C-6His
• Molecular Mass: 41.6 kDa
• Form: Liquid or Lyophilized powder
• Buffer: Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Storage: 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C.

This tyrosine-protein kinase serves as a cell-surface receptor for fibroblast growth factors (FGFs) and plays a vital role in embryonic development, cell proliferation, differentiation, and migration. It is essential for proper mesoderm patterning, axial organization, skeletogenesis, and the development of the gonadotropin-releasing hormone (GnRH) neuronal system. The kinase phosphorylates PLCG1, FRS2, GAB1, and SHB, triggering several signaling pathways upon ligand binding.
PLCG1 activation produces diacylglycerol and inositol 1,4,5-trisphosphate, while FRS2 phosphorylation recruits GRB2, GAB1, PIK3R1, and SOS1, activating RAS, MAPK/ERK, and AKT1 pathways. It promotes the phosphorylation of SHC1, STAT1, and PTPN11/SHP2, contributing to downstream signal transduction. In the nucleus, it enhances the activity of RPS6KA1 and CREB1, regulating transcription.
FGFR1 signaling is tightly controlled by IL17RD/SEF and receptor ubiquitination, internalization, and degradation, ensuring balanced cellular responses. Its role in regulating diverse cellular processes underscores its importance in development and signal transduction.