This enzyme is an S-adenosyl-L-methionine-dependent 2′-O-ribose methyltransferase that modifies the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA) by catalyzing the formation of 2′-O-methyluridine at position 1369 (Um1369), a conserved site in the peptidyl transferase domain. This modification may depend on prior methylation at Gm1370 by MRM3. The enzyme is crucial for the late-stage assembly of mtLSU, supporting efficient mitochondrial protein translation and essential mitochondrial respiratory function, though its methyltransferase activity is not necessary for assembly.
| Product Name | Recombinant Human FTSJ2 Protein |
| Accession | Q9UI43 |
| Host Species | Human |
| Gene | MRM2 |
| Source | E.coli |
