Recombinant Human Gamma-aminobutyric acid receptor subunit gamma-3 (GABRG3), partial

• Purity: >85% (SDS-PAGE)
• Host Species: Homo sapiens (Human)
• Accession: Q99928
• Gene: GABRG3
• CAT.NO: B000221
• Expression Systems: E.coli In Vivo Biotinylation in E.coli Yeast Baculovirus Mammalian cell
• Product Name: Recombinant Human Gamma-aminobutyric acid receptor subunit gamma-3 (GABRG3), partial
• Source: E.coli;In Vivo Biotinylation in E.coli;Yeast;Baculovirus;Mammalian cell
• Tag: Tag type will be determined during the manufacturing process.
• Form: Lyophilized powder
• Buffer: Tris/PBS-based buffer, 6% Trehalose.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Alternative Names: GABRG3Gamma-aminobutyric acid receptor subunit gamma-3; GABA(A) receptor subunit gamma-3
• Protein Length: Partial
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Shelf Life: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.; Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

The gamma subunit is part of the heteropentameric GABA(A) receptor, a ligand-gated chloride channel activated by gamma-aminobutyric acid (GABA), a key inhibitory neurotransmitter in the brain. GABA(A) receptors are composed of five subunits arranged around a central pore, with GABA binding sites located at the interface of the alpha and beta subunits. Upon GABA binding, these receptors open, allowing chloride ions to flow across the cell membrane in accordance with their electrochemical gradient. This chloride influx plays a critical role in inhibiting neuronal activity, contributing to the regulation of neuronal excitability and neurotransmission.