Recombinant Human Glucagon-Like Peptide 1 Receptor (GLP1R) Protein (His)

• Purity: Greater than 90% as determined by SDS-PAGE.
• Host Species: Human
• Accession: P43220
• Gene: GLP1R
• CAT.NO: B000030
• Product Name: Recombinant Human Glucagon-Like Peptide 1 Receptor (GLP1R) Protein (His)
• Source: E.coli
• Protein Expression Range: 24-145aa
• Tag: N-6His
• Molecular Mass: 18.3kDa
• Form: Liquid or Lyophilized powder
• Buffer: Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Storage: 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C.

The GLP-1 receptor is a G-protein-coupled receptor (GPCR) that binds glucagon-like peptide 1 (GLP-1). Ligand binding activates a signaling cascade that stimulates adenylyl cyclase, leading to increased intracellular cAMP levels. This receptor plays a crucial role in regulating insulin secretion in response to GLP-1, linking GLP-1 signaling to glucose homeostasis and metabolic control (by similarity). Its function is essential in mediating hormonal responses to nutrient intake, making it a key target for therapies addressing diabetes and related metabolic disorders.