Ras proteins are small GTPases that bind GDP/GTP and possess intrinsic GTPase activity, functioning as molecular switches in cellular signaling pathways. They play a pivotal role in regulating cell proliferation by transmitting signals from cell surface receptors to downstream effectors.
In addition to their physiological functions, Ras proteins can promote oncogenic processes. In colorectal cancer (CRC) cells, they contribute to tumor progression by inducing transcriptional silencing of tumor suppressor genes (TSGs) in a ZNF304-dependent manner. This dual role in normal cellular processes and cancer highlights their significance as key regulators of growth and a critical target in cancer research.
| Product Name | Recombinant Human Gtpase Kras (KRAS) Protein (His) |
| Accession | P01116 |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Host Species | Human |
| Gene | KRAS |
| Source | E.coli |
| Protein Expression Range | 2-168aa |
| Tag | N-6His |
| Molecular Mass | 23.1kDa |
| Form | Liquid or Lyophilized powder |
| Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Storage | 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C. |
