Intercellular adhesion molecule (ICAM) proteins serve as ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2), facilitating immune cell adhesion. During leukocyte trans-endothelial migration, ICAM1 engagement activates ARHGEF26/SGEF and RHOG, promoting the formation of endothelial apical cups required for leukocyte passage.
In microbial infections, ICAM1 acts as a receptor for rhinovirus A-B capsid proteins, enabling viral entry, and serves as a receptor for Coxsackievirus A21 capsid proteins. Additionally, during Kaposi’s sarcoma-associated herpesvirus (HHV-8) infection, ICAM1 is targeted for degradation by the viral E3 ubiquitin ligase MIR2, likely to evade immune surveillance by cytotoxic T-lymphocytes and natural killer (NK) cells. Through these roles, ICAM proteins are critical for immune cell interactions, microbial pathogenesis, and host-pathogen dynamics.
| Product Name | Recombinant Human ICAM-1 Protein (C-6His) |
| Accession | P05362 |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Host Species | Human |
| Gene | ICAM-1 |
| Source | Human Cells |
| Protein Expression Range | Gln28-Glu480 |
| Tag | C-6His |
| Molecular Mass | 50.54 KDa |
| Buffer | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
| Storage | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
