Recombinant Human Interleukin-13 (IL13) Protein (His), Active

• Purity: Greater than 95% as determined by SDS-PAGE.
• Host Species: Homo sapiens (Human)
• Accession: P35225
• Gene: IL13
• CAT.NO: B000219
• Expression Systems: Mammalian cell
• Product Name: Recombinant Human Interleukin-13 (IL13) Protein (His), Active
• Endotoxin: Less than 1.0 EU/μg as determined by LAL method.
• Protein Expression Range: 35-146aa
• Tag: C-6His
• Molecular Mass: 13.4 kDa
• Form: Liquid or Lyophilized powder
• Buffer: Lyophilized from a 0.2 μm filtered PBS,PH7.4
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
• Bioactivity: Active

This cytokine plays a key role in allergic inflammation and immune responses to parasite infections. It synergizes with IL-2 to regulate interferon-gamma synthesis and stimulates B-cell proliferation as well as the activation of eosinophils, basophils, and mast cells. It also regulates IL-33 activity by modulating the production of transmembrane and soluble forms of IL1RL1. It antagonizes Th1-driven proinflammatory responses, downregulating cytokines like IL-1, IL-6, IL-10, IL-12, and TNF-alpha, partly through NF-kappa-B suppression. Additionally, it induces VCAM1 in endothelial cells, aiding eosinophil recruitment.