This cytokine plays a crucial role in allergic inflammation and immune responses to parasite infections. It stimulates B-cell proliferation and activates eosinophils, basophils, and mast cells. It also regulates IL-33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1 (IL1RL1). Additionally, it antagonizes Th1-driven proinflammatory responses and downregulates the synthesis of proinflammatory cytokines like IL-1, IL-6, IL-10, IL-12, and TNF-alpha, partially through suppression of NF-kappa-B. It also affects non-hematopoietic cells, including endothelial cells, by inducing VCAM1, aiding eosinophil recruitment.
| Product Name | Recombinant Human Interleukin-13 Protein (IL13), Active |
| Accession | P35225 |
| Purity | Greater than 97% as determined by SDS-PAGE and HPLC. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Host Species | Homo sapiens (Human) |
| Gene | IL13 |
| Source | E.Coli |
| Protein Expression Range | 35-146aa |
| Tag | Tag-Free |
| Molecular Mass | 12.5 kDa |
| Form | Liquid or Lyophilized powder |
| Buffer | 0.2 μm filtered PBS, pH 7.4, lyophilized |
| Storage | 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Bioactivity | Active |
