Recombinant Human Interleukin-31 receptor subunit alpha (IL31RA), partial

• Purity: >85% (SDS-PAGE)
• Host Species: Homo sapiens (Human)
• Accession: Q8NI17
• Gene: IL31RA
• CAT.NO: B000244
• Expression Systems: E.coli In Vivo Biotinylation in E.coli Yeast Baculovirus Mammalian cell
• Product Name: Recombinant Human Interleukin-31 receptor subunit alpha (IL31RA), partial
• Source: E.coli;In Vivo Biotinylation in E.coli;Yeast;Baculovirus;Mammalian cell
• Tag: Tag type will be determined during the manufacturing process.
• Form: Lyophilized powder
• Buffer: Tris/PBS-based buffer, 6% Trehalose.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Protein Length: Partial
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Shelf Life: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature; and the stability of the protein itself.; Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized; form is 12 months at -20°C/-80°C.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

This receptor associates with OSMR to form the interleukin-31 (IL-31) receptor, activating STAT3 and, to a lesser extent, STAT1 and STAT5. It may play a role in skin immunity and is involved in mediating IL-31-induced itch, likely through the activation of cation channels TRPA1 and TRPV1. Additionally, it positively regulates the number and cycling status of immature myeloid progenitor cells in the bone marrow in vivo and enhances the survival of myeloid progenitor cells in vitro. These functions contribute to immune responses and hematopoiesis.