Integrin alpha-5/beta-1 (ITGA5) is a receptor for fibronectin and fibrinogen, recognizing the R-G-D sequence in its ligands. It binds to PLA2G2A at a distinct site (site 2) separate from the classical ligand-binding site (site 1), triggering integrin conformational changes and enhancing ligand binding at site 1.
ITGA5 also functions as a receptor for fibrillin-1 (FBN1), mediating R-G-D-dependent cell adhesion to FBN1, and fibronectin (FN1), facilitating R-G-D-dependent adhesion to FN1. Additionally, it serves as a receptor for interleukin-1 beta (IL1B), with binding essential for IL1B signaling.
In another role, the ITGA5 complex acts as a receptor for soluble CD40 ligand (CD40LG), playing a crucial role in mediating CD40/CD40LG signaling. Through its diverse ligand interactions, ITGA5
is integral to cell adhesion, signaling, and communication, impacting processes such as inflammation, extracellular matrix remodeling, and immune responses.
| Product Name | Recombinant Human ITGA5 Protein (C-6His) |
| Accession | P08648 |
| Purity | Greater than 90% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Host Species | Human |
| Gene | ITGA5 |
| Source | Human Cells |
| Protein Expression Range | Phe42-Tyr995 |
| Tag | C-6His |
| Molecular Mass | 105.11 KDa |
| Buffer | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
| Storage | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
