The G-protein coupled opioid receptor serves as a receptor for endogenous alpha-neoendorphins and dynorphins, displaying low affinity for beta-endorphins. It also interacts with various synthetic opioids and the psychoactive diterpene salvinorin A. Ligand binding induces conformational changes that activate guanine nucleotide-binding proteins (G proteins), modulating downstream effectors like adenylate cyclase and resulting in its inhibition. This signaling pathway suppresses neurotransmitter release by decreasing calcium ion currents and enhancing potassium ion conductance. The receptor plays a critical role in pain perception, reduced physical activity following synthetic opioid use, and the regulation of salivation. Additionally, it may influence arousal and autonomic as well as neuroendocrine functions. This receptor’s multifaceted roles underscore its significance in physiological and pharmacological processes.
| Product Name | Recombinant Human Kappa Opioid Receptor Protein |
| Accession | P41145 |
| Host Species | Human |
| Gene | OPRK1 |
| Source | Wheat germ |
