Recombinant Human Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-A (FCGR3A) Protein (His), Active

• Purity: Greater than 95% as determined by SDS-PAGE.
• Host Species: Homo sapiens (Human)
• Accession: P08637
• Gene: FCGR3A
• CAT.NO: B000259
• Expression Systems: Mammalian cell
• Product Name: Recombinant Human Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-A (FCGR3A) Protein (His), Active
• Endotoxin: Less than 1.0 EU/μg as determined by LAL method.
• Protein Expression Range: 17-208aa
• Tag: C-6His
• Molecular Mass: 22.61 kDa
• Form: Lyophilized powder
• Buffer: Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.2
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.; 2. Avoid repeated freeze-thaw cycles.; 3. Store working aliquots at 4°C for up to one week.; 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
• Bioactivity: The ED50 as determined by its ability to bind Human IGHG1 in functional ELISA is less than 20 ug/ml.
• Research Area: Immunology
• Protein Length: Extracellular Domain

This receptor binds the invariable Fc fragment of immunoglobulin gamma (IgG) and is optimally activated upon the binding of clustered antigen-IgG complexes on cell surfaces, triggering antibody-dependent cellular cytotoxicity (ADCC). It does not bind free monomeric IgG, preventing inappropriate activation of effector cells in the absence of an antigenic trigger. It mediates IgG effector functions on natural killer (NK) cells, stimulating cytokine production and degranulation to reduce viral load during infection. Additionally, it contributes to the generation of memory-like NK cells capable of producing IFNG and efficiently eliminating virus-infected cells via ADCC. It also regulates NK cell survival and proliferation.