Tyrosine-protein kinase FLT3 functions as a cell-surface receptor for the cytokine FLT3 ligand (FLT3LG), playing a crucial role in regulating the differentiation, proliferation, and survival of hematopoietic progenitor and dendritic cells. Upon activation, FLT3 promotes the phosphorylation of key proteins, including SHC1 and AKT1, and triggers downstream signaling pathways such as MTOR and RAS. This activation leads to the phosphorylation of kinases like MAPK1/ERK2 and MAPK3/ERK1 and other signaling molecules, including FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A/B. While wild-type FLT3 marginally activates STAT5A/B, mutations that confer constitutive kinase activity result in unchecked cell proliferation and resistance to apoptosis by hyperactivating multiple pathways. These properties make FLT3 a significant factor in hematopoietic regulation and a critical target in cancer research and therapy.
| Product Name | Recombinant Human MEK2 Protein (GST Tag) |
| Accession | P36507 |
| Host Species | Human |
| Gene | MAP2K2 |
| Source | Baculovirus insect cells |
