Recombinant Human Melanocortin receptor 4 (MC4R)

• Purity: Greater than 85% as determined by SDS-PAGE.
• Host Species: Homo sapiens (Human)
• Accession: P32245
• Gene: MC4R
• CAT.NO: B000274
• Expression Systems: in vitro E.coli expression system
• Product Name: Recombinant Human Melanocortin receptor 4 (MC4R)
• Protein Expression Range: 1-332aa
• Tag: C-terminal 10xHis-tagged
• Molecular Mass: 38.3 kDa
• Form: Liquid or Lyophilized powder
• Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Research Area: Cardiovascular
• Alternative Names: MC4-R
• Target Protein Sequence: MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
• Protein Length: Full Length
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Shelf Life: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.; Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

This receptor specifically binds to the heptapeptide core shared by adrenocorticotropic hormone (ACTH) and alpha-, beta-, and gamma-melanocyte-stimulating hormones (MSH). It plays a central role in regulating energy homeostasis and somatic growth. The receptor’s activity is mediated by G proteins, which activate adenylate cyclase, leading to increased cAMP production. This signaling cascade influences various physiological processes, including metabolism, growth, and cellular responses to hormonal signals. By modulating cAMP levels, the receptor helps coordinate the body’s response to ACTH and MSH, contributing to the maintenance of energy balance and proper growth.