Recombinant Human Nectin-2 (NECTIN2) Protein (His), Active

• Purity: Greater than 95% as determined by SDS-PAGE.
• Host Species: Homo sapiens (Human)
• Accession: Q92692
• Gene: NECTIN2
• CAT.NO: B000261
• Expression Systems: Mammalian cell
• Product Name: Recombinant Human Nectin-2 (NECTIN2) Protein (His), Active
• Endotoxin: Less than 1.0 EU/μg as determined by LAL method.
• Protein Expression Range: 32-360aa
• Tag: C-6His
• Molecular Mass: 36.58 kDa
• Form: Lyophilized powder
• Buffer: Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.2
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.; 2. Avoid repeated freeze-thaw cycles.; 3. Store working aliquots at 4°C for up to one week.; 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
• Bioactivity: The ED50 as determined by its ability to bind Human DNAM-1 in functional ELISA is less than 10 ug/ml.
• Research Area: Immunology
• Protein Length: Extracellular Domain

This protein modulates T-cell signaling and can either act as a costimulator or coinhibitor, depending on the receptor it binds to. When binding to CD226, it stimulates T-cell proliferation and cytokine production, including IL-2, IL-5, IL-10, IL-13, and IFNG. In contrast, binding to PVRIG inhibits T-cell proliferation, with these interactions being competitive. It is also considered a probable cell adhesion protein. In the context of microbial infection, it serves as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV).