This receptor is a moderately selective excitatory receptor for the neuropeptide orexin-A and, to a lesser extent, orexin-B. Upon binding to orexin-A, the receptor triggers a signaling cascade that results in an increase in cytoplasmic Ca2+^2+ levels. This rise in intracellular calcium is essential for mediating the physiological effects of orexins, such as regulating wakefulness, energy balance, and appetite control.
| Product Name | Recombinant Human Orexin Receptor Type 1 (HCRTR1) Protein (His&Myc) |
| Accession | O43613 |
| Purity | Greater than 85% as determined by SDS-PAGE. |
| Host Species | Human |
| Gene | HCRTR1 |
| Source | E.coli |
| Protein Expression Range | 1-46aa |
| Tag | N-10His&C-Myc |
| Molecular Mass | 10.4 kDa |
| Form | Liquid or Lyophilized powder |
| Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Storage | 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C. |
