This tyrosine-protein kinase serves as a cell-surface receptor for PDGFA, PDGFB, and PDGFC, playing a critical role in embryonic development, cell proliferation, survival, and chemotaxis. Its function varies by context, promoting or inhibiting cell proliferation and migration. It is essential for the differentiation of bone marrow-derived mesenchymal stem cells, skeletal development, cephalic closure, and gastrointestinal mucosa formation, including intestinal villi development via mesenchymal cell recruitment. It also facilitates cell migration and chemotaxis during wound healing and participates in platelet activation, granule secretion, and thrombin-induced aggregation.
Ligand binding (e.g., PDGFA/B/C homodimers or PDGFA-PDGFB heterodimers) triggers activation of signaling cascades, modulated by heterodimerization with PDGFRB. It phosphorylates PIK3R1, PLCG1, and PTPN11. PLCG1 activation produces diacylglycerol and inositol 1,4,5-trisphosphate, mobilizing cytosolic Ca2+and activating protein kinase C. It also activates the AKT1, HRAS, MAPK1/ERK2, MAPK3/ERK1, and STAT1/3/5 pathways. Receptor signaling is tightly regulated by dephosphorylation and rapid internalization to maintain cellular and physiological balance.
| Product Name | Recombinant Human PDGFRA Protein (C-6His) |
| Accession | P16234 |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Host Species | Human |
| Gene | PDGFRA |
| Source | Human Cells |
| Protein Expression Range | Gln24-Glu524 |
| Tag | C-6His |
| Molecular Mass | 57 KDa |
| Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Storage | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
