This protein plays a critical role in surface-dependent activation of blood coagulation. It facilitates the activation of coagulation factor XII (F12) through a reciprocal reaction after binding to negatively charged surfaces. Additionally, it releases bradykinin from high-molecular-weight kininogen (HMWK), contributing to inflammatory and vascular responses. It may also participate in the renin-angiotensin system by converting prorenin into active renin, further influencing blood pressure regulation and fluid homeostasis.
| Product Name | Recombinant Human Plasma Kallikrein (KLKB1) Protein (His) |
| Accession | P03952 |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Host Species | Human |
| Gene | KLKB1 |
| Source | Yeast |
| Protein Expression Range | 20-390aa |
| Tag | N-6His |
| Molecular Mass | 43.4kDa |
| Form | Liquid or Lyophilized powder |
| Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Storage | 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C. |
